Impact of clinical and echocardiographic response to cardiac...
The echocardiographic response (reduction of left ventricular end-systolic volume) evaluated at 6 months follow-up, demonstrated to be a better predictor of long-term mortality than improvement in...
View ArticleIncreasing dosage of clopidogrel for patients with genetic variation improves...
Among patients with stable cardiovascular disease who have a genetic variation that diminishes the response to the antiplatelet drug clopidogrel, tripling the standard daily dosage of this medication...
View ArticleResearchers find potential solution to melanoma's resistance to vemurafenib
Researchers at Moffitt Cancer Center in Tampa, Fla., and colleagues in California have found that the XL888 inhibitor can prevent resistance to the chemotherapy drug vemurafenib, commonly used for...
View ArticleStudy identifies potential new class of drug for treating ulcerative colitis
An investigational drug currently under FDA review for the treatment of rheumatoid arthritis has now shown positive results in patients with moderate-to-severe ulcerative colitis, according to...
View ArticleAzathioprine may benefit pediatric atopic dermatitis
(HealthDay) -- For pediatric patients with refractory atopic dermatitis (AD), oral azathioprine is associated with clinical improvement, and measurement of thiopurine methyltransferase (TPMT) activity...
View ArticleStudy finds potential new drug therapy for Crohn's disease
Ustekinumab, an antibody proven to treat the skin condition psoriasis, has now shown positive results in decreasing the debilitating effects of Crohn's Disease, according to researchers at the...
View ArticleAdalimumab relieves hidradenitis suppurativa
(HealthDay)—For patients with moderate-to-severe hidradenitis suppurativa (HS), a chronic skin disease characterized by painful abscesses, nodules, and draining fistulas in the axilla and groin,...
View ArticleFulyzaq approved for ART-related diarrhea in HIV/AIDS
(HealthDay)—The first medication to treat diarrhea in people with HIV/AIDS who take antiretroviral drugs has been approved by the U.S. Food and Drug Administration.
View ArticleNewer, shorter-course antibiotic shows similar effectiveness for treating...
Treatment with a newer antibiotic, tedizolid phosphate, once daily for 6 days was statistically noninferior (no worse than) in efficacy to the antibiotic linezolid twice daily for 10 days for both...
View ArticleCommon gene variants explain 42% of antidepressant response
Antidepressants are commonly prescribed for the treatment of depression, but many individuals do not experience symptom relief from treatment. The National Institute of Mental Health's STAR*D study,...
View ArticleStudy confirms everolimus can overcome trastuzumab resistance in HER-2...
A study that aimed to understand how the cancer drug everolimus helps overcome the resistance breast cancers can develop to trastuzumab has left researchers contemplating a puzzle.
View ArticleIndividual efficacy of chemotherapies
The function of the mitochondria – also defined as "power plants" within the cells – is essential as to whether, and how, some chemotherapeutic agents take effect in tissue. Scientists at the Helmholtz...
View ArticleBrodalumab demonstrates significant clinical response in psoriatic arthritis
A new study presented today at EULAR 2013, the Annual Congress of the European League Against Rheumatism, shows that treatment with brodalumab demonstrates significant clinical response and an...
View ArticleModified immune cells seek and destroy melanoma
In this issue of the Journal of Clinical Investigation, researchers led by Scott Pruitt at Duke University and Merck Research Laboratories report on a human clinical trial in which modified dendritic...
View ArticleNew IBS treatment shows potential in Phase 2 study
Patients with diarrhea-predominant irritable bowel syndrome, or IBS-D, treated with eluxadoline achieved better clinical response and experienced more symptom improvement than those using placebo,...
View ArticleAutophagy and antidepressants
FK506 binding protein 51 (FKBP51) regulates acute and chronic effects of treatment with antidepressants via autophagic pathways (processes by which cells break down and recycle their components) in...
View ArticlePatient, heal thyself: Solution to personalised treatment for chronic...
A recent discovery by scientists at A*STAR's Singapore Institute for Clinical Sciences (SICS), in close collaboration with researchers at the Singapore Immunology Network (SIgN), provides hope for a...
View ArticleResearchers harness immune system to fight pancreatic cancer
(Medical Xpress)—Pancreatic cancer ranks as the fourth-leading cause of cancer death in the United States, and is one of the most deadly forms of cancer, due to its resistance to standard treatments...
View ArticleDevelopment of autoimmunity in patients with common variable immune deficiency
Common variable immune deficiency (CVID) is a genetic disease associated with enhanced susceptibility to infection, autoimmunity, and decreased antibody production. Mutations in the tumor necrosis...
View ArticleDoes genetic variability affect long-term response to traumatic brain injury?
An individual's recovery months after a traumatic brain injury (TBI) is difficult to predict, and some of the variability in outcomes may be due to genetic differences. Subtle variations in genes that...
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